主讲人：Prof. Hongqi Xue

（Department of Biostatistics and Computational Biology University of Rochester）

时间：5月5日（周四）16：00-17：00

地点：数学科学学院 412教室

备注：摘要：In this article, we consider parameter estimation methods for unknown coefficients of nonlinear ordinary differential equation (ODE) models with measurement errors, where analytic closed-form solutions are not available. We mainly introduce our work on this field: the establishment of the asymptotic properties of nonlinear least square estimators for ODE models. Then we give a comparative review on other estimation methods, such as two-stage smoothing estimation, numerical discretization-based estimation and principal differential analysis. Finally, we show the applications to biological dynamics (HIV and influenza).